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Biomechanical control

in development and disease

The second project is to investigate the involvement of biomechanical mechanisms controlling muscle action in musculoskeletal maintenance and disease, including scoliosis, developmental dysplasia of the hip (DDH) and fracture repair. Mechanosensory organs located in muscles and myotendinous junction (MTJs) allow the nervous system to control muscle tension. Yet, our evidence shows that their malfunction affects the skeleton, including its alignment and the congruence of joints. To decipher these interactions, we combine neurobiology, developmental, molecular genetics and biomechanical studies while applying advanced techniques such as kinematics, proteomics and transcriptomics.

Lightsheet microscopy of a moue torso

Lightsheet  microscopy image of a mouse torso.

Image by Shay Eyal.

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