The third central topic in our studies is the morphogenetic mechanisms that shape bones. The unique three-dimensional morphology of each bone, which is highly intricate and irregular, has a profound effect on its function. Yet, surprisingly little is known about bone morphogenesis, partly due to the technical difficulty to document and analyze the morphogenetic sequence of developing bones. To overcome this obstacle and decipher these mechanisms, we combine advanced imaging modalities, high-throughput computer vision algorithms and computational models for analyzing temporal series of 3D images.